Searchable abstracts of presentations at key conferences in endocrinology

ea0014p10 | (1) | ECE2007

Normalization of serum testosterone level alters local GnRH-II and IL-2R mRNA expression in peripheral lymphocytes in patients with idiopathic hypogonadotrophic hypogonadism (IHH)

Tanriverdi Fatih , Akalin Hilal , Caglayan Okay , Demirkoparan Umit , Ozkul Yusuf , Dundar Munis , Bayram Fahri , Kelestimur Fahrettin

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...